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US 11,530,211 B2Granted
Dihydroindolizinone derivative
AssigneeDaiichi Sankyo Company, Limited
InventorsToshihiro Kiho, Tatsuya Yano, Satoshi Komoriya, Taisaku Tanaka
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Abstract
It is an object of the present invention to provide a new compound capable of efficiently inducing differentiation from pluripotent stem cells into insulin-producing cells. The object of the present invention is achieved by a compound represented by formula (I): wherein R1, R2, R3, n and A have the same meanings as defined in the description, respectively, or a salt thereof.
Claims27
A compound represented by formula (I):
- wherein each substituent is defined as follows:
- R1 represents a hydrogen atom, a halogen atom, or a C1-C6 alkyl group;
- R2 represents a hydrogen atom or a C1-C6 alkyl group;
- R3 represents an aryl group optionally substituted with one to four substituents independently selected from a substituent group α, a C5-C10 cycloalkenyl group optionally substituted with one to four substituents independently selected from a substituent group α, or a heterocyclyl group optionally substituted with one to four substituents independently selected from a substituent group α;
- the substituents of substituent group α are selected from the group consisting of a halogen atom, a cyano group, a carboxy group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halogeno-C1-C6 alkyl group, a halogeno-C1-C6 alkoxy group, a hydroxy C1-C6 alkyl group, a C1-C6 alkoxy C1-C6 alkoxy group, a (C1-C6 alkyl)carbonyl group, a (C1-C6 alkoxy)carbonyl group, a (C1-C6 alkoxy)carbonyloxy group, a phenyl C1-C6 alkoxy group, a non-aromatic heterocyclyl group, a carbamoyl group optionally substituted with one or two C1-C6 alkyl groups, a C1-C6 alkoxy group substituted by a carbamoyl group optionally substituted with one or two C1-C6 alkyl groups, a sulfamoyl group substituted with one or two C1-C6 alkyl groups, a phenoxy group optionally substituted with one to four substituents independently selected from a substituent group β, a phenyl group optionally substituted with one to four substituents independently selected from the substituent group β, and a benzoyl group optionally substituted with one to four substituents independently selected from the substituent group β;
- the substituents of substituent group β are selected from the group consisting of a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halogeno-C1-C6 alkyl group, a halogeno-C1-C6 alkoxy group, and a (C1-C6 alkoxy)carbonyl group;
- n represents 0 or 1;
- and
- A represents a group represented by any one of formulas (i) to (iv) below:
- wherein each substituent is defined as follows:
- ⋅ and * each represent a bond, where ⋅ is bonded to the nitrogen atom of the amido group of formula (I), and * is bonded to R3;
- R4 represents a hydrogen atom, a C1-C6 alkyl group, a halogeno-C1-C6 alkyl group, or a (C1-C6 alkoxy)carbonyl group;
- R5 represents a hydrogen atom, a halogen atom, or a C1-C6 alkyl group;
- and
- Y represents N or CH;
- or a stereoisomer or a salt thereof.
13 more elements
Dependencies are inferred from the claim text.