Compounds for the treatment of cancer

A compound of Formula (II), or a pharmaceutically acceptable salt thereof:

• wherein,
• is
• is
• wherein each RQ is independently selected from cyano, halogen, hydroxy, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C3-C7cycloalkyl, C2-C8heterocycloalkyl, heteroaryl, C2-C10heterocycloalkyl-C1-C6alkyl, C1-C6alkyl-aryl, C1-C6alkyl-C2-C10heterocycloalkyl, C1-C6alkyl-heteroaryl, C1-C6alkoxy-aryl, C1-C6alkoxy-C2-C10heterocycloalkyl, and C1-C6alkoxy-heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• n is 0, 1, 2, or 3;
• X is absent or —NR7—;
• each R1 and R5 is independently H, D, C1-C6alkyl, C1-C6haloalkyl, C1-C6heteroalkyl, C3-C8cycloalkyl, C2-C7heterocycloalkyl, aryl, or heteroaryl, wherein each of the alkyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• each R2 and R3 is independently H, D, halogen, C1-C6alkyl, C1-C6haloalkyl, aryl, monocyclic heteroaryl, —OR5, —N(R5)2, —CH2OR5, —C(═O)R5, —C(═O)OR5, —C(═O)N(R5)2, —S(═O)R5, —S(═O)2R5, or —NR5C(═O)R5, wherein each of the alkyl, haloalkyl, aryl and heteroaryl is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• R4 is —C(═O)R5, —C(═O)OR5, —C(═O)N(R6)2, —C═(O)N(OR5)(R5), —P(═O)(R6)2, —P(═O)(R6)N(R6)2, —S(═O)R6, —S(═O)2R6, —S(═O)(═NR5)R5, —N(R6)C(═O)R6, N(R6)S(═O)R6, N(R6)S(═O)2R6, —C(═O)N(R6)S(═O)2R6, —N(R6)C(═O)N(R6)2, cycloalkyl, C2-C10heterocycloalkyl, aryl, or heteroaryl, wherein each of the cycloalkyl, heterocycloalkyl, aryl and heteroaryl is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• each R6 is independently H, D, C1-C6alkyl, C1-C6haloalkyl, aryl, monocyclic heteroaryl, —OR5, —N(R5)2, —CH2OR5, —C(═O)R5, —C(═O)OR5, —C(═O)N(R5)2, —S(═O)R5, —S(═O)2R5, or —NR5C(═O)R5, wherein each of the alkyl, haloalkyl, aryl and heteroaryl is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• or
• two R6 groups on the same nitrogen atom are taken together with the nitrogen atom to which they are attached to form C2-C10heterocycloalkyl, which is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• R7 is H or C1-C6alkyl, wherein the alkyl is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• Y is NR or CR5R6;
• Z is N or CR6;
• R is selected from the group consisting of H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6heteroalkyl, C3-C8cycloalkyl, C2-C7heterocycloalkyl, aryl, and heteroaryl, wherein each of the alkyl, fluoroalkyl, and heteroalkyl is unsubstituted or substituted with hydroxy, amino, mono-C1-C6alkylamino or di-C1-C6alkylamino;
• and wherein each of the cycloalkyl, heterocycloalkyl, aryl and heteroaryl is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• R11, R12, R13, R14, R15, R16, R17, and R18 are each independently selected from the group consisting of H, F, OR5, C1-C6alkyl, C1-C6fluoroalkyl, and C1-C6heteroalkyl, wherein each of the alkyl, fluoroalkyl, and heteroalkyl is unsubstituted or substituted with hydroxy, amino, methoxy, mono-C1-C6akylamino or di-C1-C6akylamino;
• or
• R11 and R13 are taken together to form C1-C3alkylene group or C1-C3heteroalkylene group, each of which is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• or
• R11 and R15 are taken together to form C1-C3alkylene group, which is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• or
• R15 and R18 are taken together to form a bond or C1-C3alkylene group, which is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• R16 and R17 are taken together to form C1-C3alkylene group, which is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• R13 and R14 are taken together with the carbon atom to which they are attached, to form a spirocyclic C3-C8cycloalkyl;
• or
• when Z is CR6, then R17 and R6 are taken together to form a bond or C1-C3alkylene group, which is unsubstituted or substituted with one or more substituents selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, —S(═O)2C1-C4alkyl, and oxo;
• or
• when X is —NR7— and Z is CR6, then R7 and R6 are taken together with the intervening atoms to which they are attached to form a monocyclic 4, 5, or 6-membered ring;
• or
• when X is —NR7—, then R7 and R16 are taken together with the intervening atoms to which they are attached to form a monocyclic 4, 5, or 6-membered ring;
• a and b are each independently selected from 0, 1, 2, or 3;
• and
• e and f are each independently selected from 0, 1, or 2;
• wherein each of the heterocycloalkyl is independently monocyclic or bicyclic and contains 1-4 N atoms, 0-2 O atoms, 0-2 P atoms, and 0-1 S atoms in the ring, wherein each of the heteroaryl is independently 5 or 6 membered monocyclic heteroaryl that contains 1-4 N atoms, 0-1 O atoms and 0-1 S atoms, and wherein each of the heteroalkyl independently contains one or more skeletal atoms selected from O, N and S, and is attached to the rest of the molecule at a carbon or heteroatom of the heteroalkyl.