Compositions and methods for treating infections

A method of treating a protozoan infection, comprising administering to a patient in need thereof a compound having the structure of formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or salt:

• wherein:
• R1 is H, C1-6 alkyl, C3-6 cycloalkyl, C4-8 cycloalkylalkyl, or halogen;
• W is N or CR18 and Z is N or CR17, provided that at least one of W and Z is N;
• R2, R3, R4, R5, R6, R7, R8, R9, R17, and R18 are independently selected from H, C1-6 alkyl, C3-6 cycloalkyl, hydroxyl and fluorine;
• provided that at least four of R2, R3, R4, R5, R6, R7, R8, and R9 are H;
• if W is N, then none of R2, R3, R6, and R7 is hydroxyl;
• and if Z is N, then none of R4, R5, R8, and R9 is hydroxyl;
• and
• R10 is substituted or unsubstituted C6-10 aryl or 5- to 10-membered heteroaryl,
• wherein the infection is caused by an Apicomplexan protozoan, wherein the genus of the protozoan is selected from Toxoplasma, Leishmania, and Trypanosoma.