Compounds for treating mitochondrial disease

A compound of general structure (I):

• wherein
• wherein L is selected from
• —CH2—CH2—NH—C(O)—CH2—,
• —CH2—CH2—NH—C(NH2)═,
• —CH2—CH2—NH—C(O)—CH2—NH—C(NH2)═,
• —CH2—CH2—CH2—NH—C(NH2)═,
• —CH2—CH2—NH—C(Me)═,
• —CH2—CH2—NH—C(O)—CH2—NH—C(Me)═,
• —CH2—CH2—CH2—NH—C(Me)═,
• —CH2—CH2—NR1′—C(NH2)═,
• —C(CO2H)—CH2—CH2—CH2—,
• —C(CO2H)—CH2—CH2—CH2—NH—C(NH2)—,
• —C(CO2H)—CH2—,
• —C(CO2H)—CH2—CH2—,
• —C(CO2H)—CH2—CH2—CH2—CH2—,
• —CH2—CH2—CH2—CH2—,
• —CH2—CH2—CH2—CH2—CH2—,
• —CHR2′—C(O)—,
• —CHR2′—CH2—,
• —CHR5—CH2—NR5′—C(Me)═,
• —CHR2′—CH2—CH2—,
• —CH2—CH2—CHR1′—,
• —CH2—CH2—CHR1′—NH—C(O)—C(Me)-,
• —CH2—CHR1′—,
• —CH2—CHR1′—NH—C(Me)═, or
• —CHR5—CH2—CH2—CHR5′—;
• R1 and R2 are each independently selected from H, C1-C6 alkyl or C1-C6 alkenyl, or R1 is joined with R1′ in a cyclic structure and/or R2 is joined with R2′ in a cyclic structure, or R1 and R2 are joined together and thus form a second linker between the amide nitrogen atom and the distal nitrogen atom (N*) wherein L is a linker comprising 1 to 10 optionally substituted backbone atoms selected from carbon, nitrogen and oxygen;
• R3 is selected from H, C1-C6 alkyl or C1-C6 alkenyl, wherein the alkyl or alkenyl moiety may be substituted with one or more halogen atoms or (halo)alkoxy moieties, or R3 is absent when the distal nitrogen atom is part of an imine moiety;
• and
• R4 is absent;
• and
• R5 is joined with R5′ in a cyclic structure, and
• X is absent.