Carbamate compounds and methods of making and using same

A method of treating epilepsy in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound represented by:

• wherein
• L3 is a bond, —CH2—, —S(O)2—, or —C(O)—;
• R7 is phenyl;
• wherein R7 is optionally substituted by one, two, or three moieties independently selected from Rh;
• Ra and Rb are independently selected, for each occurrence, from the group consisting of hydrogen and C1-3alkyl;
• wherein C1-3alkyl is optionally substituted by one or more substituents selected from halogen, cyano, oxo, hydroxyl, heterocycle, and phenyl;
• or Ra and Rb, when they occur together with the nitrogen to which they are attached, form a 4-6 membered saturated heterocyclic ring, which may have an additional heteroatom selected from O, S, and N, or a spirocyclic ring selected from 8-oxa-2-azaspiro[4.5]decane and 2,8-diazaspiro[4.5]decane, wherein the 4-6 membered saturated heterocyclic ring or the spirocyclic ring are optionally substituted by one or more substituents selected from the group consisting of halogen, cyano, oxo, C1-6alkyl, —S(O)w—C1-6alkyl (where w is 0, 1 or 2), hydroxyl, —C(O)—C1-6alkyl, —NH2, and —NH—C(O)—C1-6alkyl;
• Rc is selected from the group consisting of halogen, hydroxyl, C1-6alkyl (optionally substituted by one, two, or three halogens), and C1-6alkoxy (optionally substituted by one, two, or three halogens);
• and
• Rh is selected from the group consisting of:
• halogen, phenyl (optionally substituted by one, two, or three moieties each independently selected from Rc), hydroxyl, cyano, C1-6alkyl (optionally substituted by one, two or three halogens), C1-6alkoxy (optionally substituted by one, two or three halogens), RaRbN—, Ra—C(O)NRa—, RaRbN—SO2—, RaRbN—C(O)—, Ra—S(O)w— (wherein w is 0, 1 or 2), Ra—SO2—NRb—, and heteroaryl (optionally substituted by one, two or three moieties each independently selected from Rc);
• or a stereoisomer or pharmaceutically acceptable salt thereof.