IL-6 inhibitors and methods of treatment

A compound of Formula (XV), or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 is selected from the group consisting of pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, isothiazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, oxatriazolyl, pyrazinyl, pyridyl, pyridazinyl, pyrimidinyl, azetidinonyl, azetidinethionyl, pyrrolidinonyl, pyrrolidinethionyl, piperidinonyl, piperidinethionyl, tetrahydropyrimidinonyl, tetrahydropyrimidinethionyl, imidazolidinonyl, imidazolidinethionyl, 1,3-diazetidinonyl, 1,3-diazetidinethionyl, 1,2-oxazetidinyle, 1,2-thiazetidinyl, isoxazolidinyl, isothiazolidinyl, 1,2-oxazinanyl, 1,2-thiazinanyl, pyrimidinedionyl, 5-methylpyrimidine-2,4(1H,3H)-dionyl, isoxazol-5(2H)-onyl, 1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dionyl, 1,4,5,6-tetrahydro-7H-indol-7-onyl, 1H-pyrrolo[2,3-b]pyridyl, quinazoline-2,4(1H,3H)-dionyl, furo[2,3-d]pyrimidine-2,4(1H,3H)-dionyl, 1,3-dihydro-2H-benzo[d]imidazol-2-onyl, 1H-indole-4,7-dionyl, 5,6-dimethyl-1H-indole-4,7-dionyl, 5,6-dihydro-1H-indole-4,7-dionyl, 4,5-dihydropyrano[3,4-b]pyrrol-7(1H)-onyl, 1,4,5,6-tetrahydro-7H-pyrrolo[2,3-c]pyridin-7-onyl, 1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-onyl, pyrano[3,4-b]pyrrol-7(1H)-onyl, 1,3-dihydro-2H-imidazol-2-onyl, 4-fluoro-1H-pyrazolyl, 3,4-difluoro-1H-pyrazolyl, 3-fluoro-1H-pyrazolyl, 4-chloro-1H-pyrazolyl, 3,4-dichloro-1H-pyrazolyl, 3-chloro-1H-pyrazolyl, 3-methoxy-1H-pyrazolyl, 1H-pyrazol-3-yl acetate, 4-methoxy-1H-pyrazolyl, 1H-pyrazol-4-yl acetate, N-(1H-pyrazol-4-yl)acetamidyl, N,N-dimethyl-1H-pyrazol-4-amino, N,N-dimethyl-1H-pyrazol-3-amino, 4-(trifluoromethyl)-1H-pyrazolyl, 3-(trifluoromethyl)-1H-pyrazolyl, N-(1H-pyrazol-3-yl)acetamide, and 1H-pyrazol-3-amino;
• each R2 is independently halo, cyano, —OR5, NO2, alkyl, or —NR6R7;
• each R4 is independently halo, cyano, —OR5, NO2, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, or —NR6R7;
• each R5 is independently hydrogen or alkyl;
• each R6 is independently hydrogen or alkyl;
• each R7 is independently hydrogen or alkyl;
• D is —O—;
• Y is a bond, —O—N(R6)—;
• n is 0, 1, or 2;
• o is 0;
• and
• p is 2, 3, or 4.