Alpha-5 beta-1 inhibitors

A compound of Formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• m is 1 or 2;
• A1 is C(R4) or N;
• A2 is C(R10) or N;
• X is a bond, —C(R15)(R16)— or —N(R15)—;
• L1 is bond, —C(O)—, —C(O)O—, —O—, —S—, —NH—, —C(O)NH—, —NHC(O)—, —S(O)2—, —S(O)NH—, —(CH2)z1—NH—, —(CH2)z3—N((CH2)z4CH3)—C(═O)—, L11-substituted or unsubstituted alkylene, unsubstituted heteroalkylene, L11-substituted or unsubstituted cycloalkylene, L11-substituted or unsubstituted heterocycloalkylene, L11-substituted or unsubstituted arylene, or L11-substituted or unsubstituted heteroarylene;
• L11 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R1 is hydrogen, R100-substituted or unsubstituted alkyl, R100-substituted or unsubstituted heteroalkyl, R100-substituted or unsubstituted cycloalkyl, or —[P(═O)(OH)O—]n—H, where n is an integer from 1 to 3;
• R100 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R101-substituted or unsubstituted alkyl, R101-substituted or unsubstituted heteroalkyl, R101-substituted or unsubstituted cycloalkyl, R101-substituted or unsubstituted heterocycloalkyl, R101-substituted or unsubstituted aryl, or R101-substituted or unsubstituted heteroaryl;
• R101 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCH2X2, —OCHX22, —SOn2R2A, —SOv2NR2AR2B, —CN, —C(O)R2A, —C(O)OR2A, —C(O)NR2AR2B, —OR2A, —ONR2AR2B, —NHC(O)NR2AR2B, —N(O)m2, —NR2AR2B, —NHNR2AR2B, —NR2ASO2R2B, —NR2AC(O)R2B, —NR2AC(O)OR2B, —NR2AOR2B, —N3, R200-substituted or unsubstituted alkyl, R200-substituted or unsubstituted heteroalkyl, R200-substituted or unsubstituted cycloalkyl, R200-substituted or unsubstituted heterocycloalkyl, R200-substituted or unsubstituted aryl, or R200-substituted or unsubstituted heteroaryl;
• R2A and R2B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R200-substituted or unsubstituted alkyl, R200-substituted or unsubstituted heteroalkyl, R200-substituted or unsubstituted cycloalkyl, R200-substituted or unsubstituted heterocycloalkyl, R200-substituted or unsubstituted aryl, or R200-substituted or unsubstituted heteroaryl;
• R200 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R201-substituted or unsubstituted alkyl, R201-substituted or unsubstituted heteroalkyl, R201-substituted or unsubstituted cycloalkyl, R201-substituted or unsubstituted heterocycloalkyl, R201-substituted or unsubstituted aryl, or R201-substituted or unsubstituted heteroaryl;
• R201 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R3 is hydrogen, halogen, —CX33, —CHX32, —CH2X3, —OCX33, —OCH2X3, —OCHX32, —SOn3R3A, —SOv3NR3AR3B, —CN, —C(O)R3A, —C(O)OR3A, —C(O)NR3AR3B, —OR3A, —ONR3AR3B, —NHC(O)NR3AR3B, —N(O)m3, —NR3AR3B, —NHNR3AR3B, —NR3ASO2R3B, —NR3AC(O)R3B, —NR3AC(O)OR3B, —NR3AOR3B, —N3, R300-substituted or unsubstituted alkyl, R300-substituted or unsubstituted heteroalkyl, R300-substituted or unsubstituted cycloalkyl, R300-substituted or unsubstituted heterocycloalkyl, R300-substituted or unsubstituted aryl, or R300-substituted or unsubstituted heteroaryl;
• R3A and R3B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R300-substituted or unsubstituted alkyl, R300-substituted or unsubstituted heteroalkyl, R300-substituted or unsubstituted cycloalkyl, R300-substituted or unsubstituted heterocycloalkyl, R300-substituted or unsubstituted aryl, or R300-substituted or unsubstituted heteroaryl;
• R300 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R301-substituted or unsubstituted alkyl, R301-substituted or unsubstituted heteroalkyl, R301-substituted or unsubstituted cycloalkyl, R301-substituted or unsubstituted heterocycloalkyl, R301-substituted or unsubstituted aryl, or R301-substituted or unsubstituted heteroaryl;
• R301 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R4 is hydrogen, halogen, —CX43, —CHX42, —CH2X4, —OCX43, —OCH2X4, —OCHX42, —SOn4R4A, —SOv4NR4AR4B, —CN, —C(O)R4A, —C(O)OR4A, —C(O)NR4AR4B, —ONR4AR4B, —NHC(O)NR4AR4B, —N(O)m4, —NR4AR4B, —NHNR4AR4B, —NR4ASO2R4B, —NR4AC(O)R4B, —NR4AC(O)OR4B, —NR4AOR4B, —N3, R400-substituted or unsubstituted alkyl, R400-substituted or unsubstituted cycloalkyl, R400-substituted or unsubstituted heterocycloalkyl, R400-substituted or unsubstituted aryl, or R400-substituted or unsubstituted heteroaryl;
• R4A and R4B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R400-substituted or unsubstituted alkyl, R400-substituted or unsubstituted heteroalkyl, R400-substituted or unsubstituted cycloalkyl, R400-substituted or unsubstituted heterocycloalkyl, R400-substituted or unsubstituted aryl, or R400-substituted or unsubstituted heteroaryl;
• R400 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R401-substituted or unsubstituted alkyl, R401-substituted or unsubstituted heteroalkyl, R401-substituted or unsubstituted cycloalkyl, R401-substituted or unsubstituted heterocycloalkyl, R401-substituted or unsubstituted aryl, or R401-substituted or unsubstituted heteroaryl;
• R401 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R5 is hydrogen, halogen, —CX53, —CHX52, —CH2X5, —OCX53, —OCH2X5, —OCHX52, —SOn5R5A, —SOv5NR5AR5B, —CN, —C(O)R5A, —C(O)OR5A, —C(O)NR5AR5B, —OR5A, —ONR5AR5B, —NHC(O)NR5AR5B, —N(O)m5, —NR5AR5B, —NHNR5AR5B, —NR5ASO2R5B, —NR5AC(O)R5B, —NR5AC(O)OR5B, —NR5AOR5B, —N3, R500-substituted or unsubstituted alkyl, R500-substituted or unsubstituted heteroalkyl, R500-substituted or unsubstituted cycloalkyl, R500-substituted or unsubstituted heterocycloalkyl, R500-substituted or unsubstituted aryl, or R500-substituted or unsubstituted heteroaryl;
• R5A and R5B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R500-substituted or unsubstituted alkyl, R500-substituted or unsubstituted heteroalkyl, R500-substituted or unsubstituted cycloalkyl, R500-substituted or unsubstituted heterocycloalkyl, R500-substituted or unsubstituted aryl, or R500-substituted or unsubstituted heteroaryl;
• R500 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R501-substituted or unsubstituted alkyl, R501-substituted or unsubstituted heteroalkyl, R501-substituted or unsubstituted cycloalkyl, R501-substituted or unsubstituted heterocycloalkyl, R501-substituted or unsubstituted aryl, or R501-substituted or unsubstituted heteroaryl;
• R501 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R6 is hydrogen, halogen, —CX63, —CHX62, —CH2X6, —OCX63, —OCH2X6, —OCHX62, —SOn6R6A, —SOv6NR6AR6B, —CN, —C(O)R6A, —C(O)OR6A, —C(O)NR6AR6B, —OR6A, —ONR6AR6B, —NHC(O)NR6AR6B, —N(O)m6, —NR6AR6B, —NHNR6AR6B, —NR6ASO2R6B, —NR6AC(O)R6B, —NR6AC(O)OR6B, —NR6AOR6B, —N3, R600-substituted or unsubstituted alkyl, R600-substituted or unsubstituted heteroalkyl, R600-substituted or unsubstituted cycloalkyl, R600-substituted or unsubstituted heterocycloalkyl, R600-substituted or unsubstituted aryl, or R600-substituted or unsubstituted heteroaryl;
• R6A and R6B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R200-substituted or unsubstituted alkyl, R600-substituted or unsubstituted heteroalkyl, R600-substituted or unsubstituted cycloalkyl, R600-substituted or unsubstituted heterocycloalkyl, R600-substituted or unsubstituted aryl, or R600-substituted or unsubstituted heteroaryl;
• R600 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R601-substituted or unsubstituted alkyl, R601-substituted or unsubstituted heteroalkyl, R601-substituted or unsubstituted cycloalkyl, R201-substituted or unsubstituted heterocycloalkyl, R601-substituted or unsubstituted aryl, or R601-substituted or unsubstituted heteroaryl;
• R601 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R7 is hydrogen, halogen, —CX73, —CHX72, —OCX73, —OCH2X7, —OCHX72, —SOn7R7A, —SOv7NR7AR7B, —CN, —C(O)R7A, —C(O)OR7A, —C(O)NR7AR7B, —OR7A, —ONR7AR7B, —NHC(O)NR7AR7B, —N(O)m7, —NR7AR7B, —NHNR7AR7B, —NR7ASO2R7B, —NR7AC(O)R7B, —NR7AC(O)OR7B, —NR7AOR7B, —N3, R700-substituted or unsubstituted alkyl, R700-substituted or unsubstituted heteroalkyl, R700-substituted or unsubstituted cycloalkyl, R700-substituted or unsubstituted heterocycloalkyl, R700-substituted or unsubstituted aryl, or R700-substituted or unsubstituted heteroaryl;
• R7A and R7B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R700-substituted or unsubstituted alkyl, R700-substituted or unsubstituted heteroalkyl, R700-substituted or unsubstituted cycloalkyl, R700-substituted or unsubstituted heterocycloalkyl, R700-substituted or unsubstituted aryl, or R700-substituted or unsubstituted heteroaryl;
• R700 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R701-substituted or unsubstituted alkyl, R701-substituted or unsubstituted heteroalkyl, R701-substituted or unsubstituted cycloalkyl, R701-substituted or unsubstituted heterocycloalkyl, R701-substituted or unsubstituted aryl, or R701-substituted or unsubstituted heteroaryl;
• R701 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R7 and R15 are optionally joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein the substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with a substituent group;
• R8 is hydrogen, halogen, —CX83, —CHX82, —CH2X8, —OCX83, —OCH2X8, —OCHX82, —SOn8R8A, —SOv8NR8AR8B, —CN, —C(O)R8A, —C(O)OR8A, —C(O)NR8AR8B, —OR8A, —ONR8AR8B, —NHC(O)NR8AR8B, —N(O)m8, —NR8AR8B, —NHNR8AR8B, —NR8ASO2R8B, —NR8AC(O)R8B, —NR8AC(O)OR8B, —NR8AOR8B, —N3, R800-substituted or unsubstituted alkyl, R800-substituted or unsubstituted heteroalkyl, R800-substituted or unsubstituted cycloalkyl, R800-substituted or unsubstituted heterocycloalkyl, R800-substituted or unsubstituted aryl, or R800-substituted or unsubstituted heteroaryl;
• R8A and R8B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R800-substituted or unsubstituted alkyl, R800-substituted or unsubstituted heteroalkyl, R800-substituted or unsubstituted cycloalkyl, R800-substituted or unsubstituted heterocycloalkyl, R800-substituted or unsubstituted aryl, or R800-substituted or unsubstituted heteroaryl;
• R800 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R801-substituted or unsubstituted alkyl, R801-substituted or unsubstituted heteroalkyl, R801-substituted or unsubstituted cycloalkyl, R801-substituted or unsubstituted heterocycloalkyl, R801-substituted or unsubstituted aryl, or R801-substituted or unsubstituted heteroaryl;
• R801 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R9 is hydrogen, halogen, —CX93, —CHX92, —CH2X9, —OCX93, —OCH2X9, —OCHX92, —SOn9R9A, —SOv9NR9AR9B, —CN, —C(O)R9A, —C(O)OR9A, —C(O)NR9AR9B, —OR9A, —ONR9AR9B, —NHC(O)NR9AR9B, —N(O)m9, —NR9AR9B, —NHNR9AR9B, —NR9ASO2R9B, —NR9AC(O)R9B, —NR9AC(O)OR9B, —NR9AOR9B, —N3, R900-substituted or unsubstituted alkyl, R900-substituted or unsubstituted heteroalkyl, R900-substituted or unsubstituted cycloalkyl, R900-substituted or unsubstituted heterocycloalkyl, R900-substituted or unsubstituted aryl, or R900-substituted or unsubstituted heteroaryl;
• R9A and R9B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R900-substituted or unsubstituted alkyl, R900-substituted or unsubstituted heteroalkyl, R900-substituted or unsubstituted cycloalkyl, R900-substituted or unsubstituted heterocycloalkyl, R900-substituted or unsubstituted aryl, or R900-substituted or unsubstituted heteroaryl;
• R900 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R901-substituted or unsubstituted alkyl, R901-substituted or unsubstituted heteroalkyl, R901-substituted or unsubstituted cycloalkyl, R901-substituted or unsubstituted heterocycloalkyl, R901-substituted or unsubstituted aryl, or R901-substituted or unsubstituted heteroaryl;
• R901 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R9 and R11 are optionally joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein the substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteraryl is substituted with a substituent group;
• R10 is hydrogen, halogen, —CX103, —CHX102, —CH2X10, —OCX103, —OCH2X10, —OCHX102, —SOn10R10A, —SOv10NR10AR10B, —CN, —C(O)R10A, —C(O)OR10A, —C(O)NR10AR10B, —OR10A, —ONR10AR10B, —NHC(O)NR10AR10B, —N(O)m10, —NR10AR10B, —NHNR10AR10B, —NR10A, —SO2R10B, —NR10AC(O)R10B, —NR10AC(O)OR10B, —NR10AOR10B, —N3, R101′-substituted or unsubstituted alkyl, R101′-substituted or unsubstituted heteroalkyl, R101′-substituted or unsubstituted cycloalkyl, R101′-substituted or unsubstituted heterocycloalkyl, R101′-substituted or unsubstituted aryl, or R101′-substituted or unsubstituted heteroaryl;
• R10A and R10B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R101′-substituted or unsubstituted alkyl, R101′-substituted or unsubstituted heteroalkyl, R101′-substituted or unsubstituted cycloalkyl, R101′-substituted or unsubstituted heterocycloalkyl, R101′-substituted or unsubstituted aryl, or R101′-substituted or unsubstituted heteroaryl;
• R101′is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R102-substituted or unsubstituted alkyl, R102-substituted or unsubstituted heteroalkyl, R102-substituted or unsubstituted cycloalkyl, R102-substituted or unsubstituted heterocycloalkyl, R102-substituted or unsubstituted aryl, or R102-substituted or unsubstituted heteroaryl;
• R102 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R11 is hydrogen, halogen, —CX113, —CHX112, —CH2X11, —OCX113, —OCH2X11, —OCHX112, —SOn11R11A, —SOv11NR11AR11B, —CN, —C(O)R11A, —C(O)OR11A, —C(O)NR11AR11B, —OR11A, —ONR11AR11B, —NHC(O)NR11AR11B, —N(O)m11, —NR11AR11B, —NHNR11AR11B, —NR11ASO2R11B, —NR11AC(O)R11B, —NR11AC(O)OR11B, —NR11AR11B, —N3, R110-substituted or unsubstituted alkyl, R110-substituted or unsubstituted heteroalkyl, R110-substituted or unsubstituted cycloalkyl, R110-substituted or unsubstituted heterocycloalkyl, R110-substituted or unsubstituted aryl, or R110-substituted or unsubstituted heteroaryl;
• R11A and R11B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R110-substituted or unsubstituted alkyl, R110-substituted or unsubstituted heteroalkyl, R110-substituted or unsubstituted cycloalkyl, R110-substituted or unsubstituted heterocycloalkyl, R110-substituted or unsubstituted aryl, or R110-substituted or unsubstituted heteroaryl;
• R110 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, Rill-substituted or unsubstituted alkyl, R111-substituted or unsubstituted heteroalkyl, R111-substituted or unsubstituted cycloalkyl, R111-substituted or unsubstituted heterocycloalkyl, R111-substituted or unsubstituted aryl, or R111-substituted or unsubstituted heteroaryl;
• R111 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R12 is hydrogen, halogen, —CX123, —CHX122, —CH2X12, —OCX123, —OCH2X12, —OCHX122, —SOn12R12A, —SOv12NR12AR12B, —CN, —C(O)R12A, —C(O)OR12A, —C(O)NR12AR12B, —NR12A, —ONR12AR12B, —NHC(O)NR12AR12B, —N(O)m12, —NR12AR12B, —NHNR12AR12B, —NR12ASO2R12B, —NR12AC(O)R12B, —NR12AC(O)OR12B, —NR12AOR12B, —N3, R120-substituted or unsubstituted alkyl, R120-substituted or unsubstituted heteroalkyl, R120-substituted or unsubstituted cycloalkyl, R120-substituted or unsubstituted heterocycloalkyl, R120-substituted or unsubstituted aryl, or R120-substituted or unsubstituted heteroaryl;
• R12A and R12B are independently hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R120-substituted or unsubstituted alkyl, R120-substituted or unsubstituted heteroalkyl, R120-substituted or unsubstituted cycloalkyl, R120-substituted or unsubstituted heterocycloalkyl, R120-substituted or unsubstituted aryl, or R120-substituted or unsubstituted heteroaryl;
• R120 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R121-substituted or unsubstituted alkyl, R121-substituted or unsubstituted heteroalkyl, R121-substituted or unsubstituted cycloalkyl, R121-substituted or unsubstituted heterocycloalkyl, R121-substituted or unsubstituted aryl, or R121-substituted or unsubstituted heteroaryl;
• R121 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R15 is hydrogen, —C(O)OR15A, —C(O)R15A, —SO2R15A, R150-substituted or unsubstituted alkyl, R150-substituted or unsubstituted heteroalkyl, R150-substituted or unsubstituted cycloalkyl, R150-substituted or unsubstituted heterocycloalkyl, R150-substituted or unsubstituted aryl, or R150-substituted or unsubstituted heteroaryl;
• R15A is hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R150-substituted or unsubstituted alkyl, R150-substituted or unsubstituted heteroalkyl, R150-substituted or unsubstituted cycloalkyl, R150-substituted or unsubstituted heterocycloalkyl, R150-substituted or unsubstituted aryl, or R150-substituted or unsubstituted heteroaryl;
• R150 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R151-substituted or unsubstituted alkyl, R151-substituted or unsubstituted heteroalkyl, R151-substituted or unsubstituted cycloalkyl, R151-substituted or unsubstituted heterocycloalkyl, R151-substituted or unsubstituted aryl, or R151-substituted or unsubstituted heteroaryl;
• R151 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R16 is hydrogen, —C(O)OR16A, —C(O)R16A, —SO2R16A, R160-substituted or unsubstituted alkyl, R160-substituted or unsubstituted heteroalkyl, R160-substituted or unsubstituted cycloalkyl, R160-substituted or unsubstituted heterocycloalkyl, R160-substituted or unsubstituted aryl, or R160-substituted or unsubstituted heteroaryl;
• R16A is hydrogen, halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OC HCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, R160-substituted or unsubstituted alkyl, R160-substituted or unsubstituted heteroalkyl, R160-substituted or unsubstituted cycloalkyl, R160-substituted or unsubstituted heterocycloalkyl, R160-substituted or unsubstituted aryl, or R160-substituted or unsubstituted heteroaryl;
• R160 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, R161-substituted or unsubstituted alkyl, R161-substituted or unsubstituted heteroalkyl, R161-substituted or unsubstituted cycloalkyl, R161-substituted or unsubstituted heterocycloalkyl, R161-substituted or unsubstituted aryl, or R161-substituted or unsubstituted heteroaryl;
• R161 is independently halogen, —CF3, —CBr3, —CCl3, —CI3, —CHF2, —CHBr2, —CHCl2, —CHI2, —CH2F, —CH2Br, —CH2Cl, —CH2I, —OCF3, —OCBr3, —OCCl3, —OCI3, —OCHF2, —OCHBr2, —OCHCl2, —OCHI2, —OCH2F, —OCH2Br, —OCH2Cl, —OCH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —N(O)2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, and X12 are each independently —F, —Cl, —Br, or —I;
• n2, n3 n4, n5, n6, n7, n8, n9, n10, n11, and n12 are independently an integer from 0 to 4;
• m2, m3, m4, m5, m6, m7, m8, m9, m10, m11, and m12 are independently 1 or 2;
• v2, v3, v4, v5, v6, v7, v8, v9, v10, v11, and v12 are independently 1 or 2;
• z1 is an integer from 1 to 10;
• z3 is an integer from 1 to 10;
• and
• z4 is an integer from 0 to 9.