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US 11,530,132 B2Granted
Composition comprising porous silica particles carrying a cell fate modulating factor
AssigneeLemonex Inc.
InventorsDal-Hee Min, Cheolhee Won, Sejin Park, Seongchan Kim
Life of this patent
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Abstract
A composition includes porous silica particles to carry a cell fate modulating factor therein. A method for modulating cell fate includes treating various cells with the composition. The cell fate modulating factor is delivered to a stable target receptor, toxicity to subject cells for delivery may be reduced, a fate of the subject cells can be controlled through sustained release of at least 99 wt. % of the cell fate modulating factor.
Claims11
A composition, comprising:
- a cell fate modulating factor in a therapeutically effective amount to treat a subject in need thereof;
- porous silica particles which carry the cell fate modulating factor on a surface of the particle or inside pores of the particle, the porous silica particles having t of 20 to 120 hours at which an absorbance of the porous silica particles after t hours becomes half an initial absorbance of the porous silica particles, the porous silica particles having an average diameter of 100 to 1,000 nm and an average pore diameter of 1 to 100 nm.
Dependencies are inferred from the claim text.