Technique to improve deep brain stimulation targeting during intraoperative microelectrode recordings
AssigneeThe Trustees of the Stevens Institute of Technology
InventorsGeorge McConnell, Hanyan Li
Life of this patent
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Abstract
A method of localizing brain regions for the purpose of guiding placement of electrodes and related implants is disclosed. The inventive method involves effecting a pulse in a patient's brain, temporally aligning readings taken from an electrode at various depths, measuring local field potentials at each depth during interstimulus intervals, performing a coherence analysis comparing the local field potential measurements of the different depths, and determining a corresponding brain region for the depths compared.
Claims19
A method for localizing brain regions of a patient, comprising the steps of:
- i) providing a first set of stimulus pulses to the patient's brain at a first location, said first set of stimulus pulses having randomized amplitudes;
- ii) recording a first dataset, including a first set of local field potentials, produced in response to said first set of stimulus pulses;
- iii) providing a second set of stimulus pulses to the patient's brain at a second location which is spaced a distance from said first location, said second set of stimulus pulses having randomized amplitudes;
- iv) recording a second dataset, including a second set of local field potentials, produced in response to said second set of stimulus pulses;
- v) calculating frequency domain coherence values from said first set of local field potentials and said second set of local field potentials;
- vi) recording said frequency domain coherence values in a comparison dataset;
- vii) analyzing said comparison dataset to obtain analysis results;
- and
- viii) using said analysis results to estimate at least one of said first location and said second location with respect to its functional location in the patient's brain.
Dependencies are inferred from the claim text.