Obstructive sleep apnea treatment devices, systems and methods

A nerve stimulation system, comprising:

• a stimulation delivery lead;
• and
• an implantable neurostimulator connected to the stimulation delivery lead, wherein the neurostimulator is programmed to:
• deliver nerve stimulation therapy to a subject at a first intensity during a first therapy period of the nerve stimulation therapy, wherein the first intensity is within a range having a lower bound and an upper bound, wherein the subject is awake during at least an initial portion of the first therapy period, and wherein the upper bound is a discomfort threshold;
• detect a wakefulness of the subject;
• and
• modify, based on the detected wakefulness of the subject, the delivery of the nerve stimulation therapy from the first intensity to a second intensity, thereby initiating a second therapy period of the nerve stimulation therapy subsequent to the first therapy period, wherein the second intensity is different from the first intensity, wherein the subject is asleep during at least an initial portion of the second therapy period,
• wherein the neurostimulator is configured to deliver the nerve stimulation therapy to a nerve of the subject for treating a respiratory condition of the subject.