Apparatus and methods for restoring tissue

A method of tissue restoration in a blood vessel of a subject comprising:

• providing a catheter into the blood vessel, the catheter comprising:
• a catheter shaft extending from a proximal end to a distal tip and having a translucent distal segment, the catheter shaft defining a plurality of lumens including an inflation lumen, a guidewire lumen, and a light fiber lumen;
• a drug coated balloon positioned on the distal segment proximal to the distal tip in fluid communication with the inflation lumen, the drug coated distal balloon comprising a translucent material;
• and
• a light fiber positioned in the catheter shaft in the light fiber lumen and extending through the distal segment;
• inflating the coated balloon to a predetermined pressure for a first predetermined amount of time to allow the coated drug to transfer to a target area;
• activating a light source connected to the light fiber for a second predetermined amount of time after the first predetermined amount of time has completed, while keeping the drug coated balloon inflated, thereby providing light transmission through the distal segment and the coated balloon to activate the drug in the target area to form a cast shape and to prop the vessel open.

An apparatus comprising

• a catheter shaft extending from a proximal end to a distal tip and having a translucent distal segment, the catheter shaft defining lumens including an inflation lumen and a light fiber lumen;
• a coated balloon positioned on the distal segment proximal to the distal tip in fluid communication with the inflation lumen, the coated distal balloon comprising a translucent material and a coated material on an outer surface of the coated balloon;
• and
• wherein, in use, the coated balloon is configured to at least partially contact a vessel wall in an expanded state;
• and
• wherein the coated balloon is configured so that a therapeutically effective quantity of coated material is transferred from the outer surface of the coated balloon to the target area when the coated balloon contacts the vessel wall in a target area in an expanded state;
• a light fiber positioned in the catheter shaft in the light fiber lumen and extending through the translucent distal segment;
• wherein the catheter shaft is shielded along the length of the catheter shaft until the distal segment, providing light transmission out of the distal segment and the coated balloon and the coated material is a light-activated treatment compound.