Tangential flow filter system for the filtration of materials from biologic fluids
AssigneeMinnetronix, Inc.
InventorsEmily Rolfes Meyering, Gary Seim, Abhi Vase, Ben Krehbiel, Blake Hedstrom, Aaron McCabe, Jack Mondry
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Abstract
Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. In an example, CSF is separated into a permeate and retentate using a tangential flow filter. The retentate is filtered again and then returned to the subject with the permeate. During operation of the system, various parameters may be modified, such as flow rate and waste rate.
Claims19
A system for filtering materials from cerebrospinal fluid (CSF) of a human or animal subject, the system comprising:
- a catheter assembly including a first fluid pathway and a second fluid pathway;
- a first tangential flow filter coupled to the catheter assembly, the first tangential flow filter having a fluid inlet in communication with the first fluid pathway, a permeate outlet in fluid communication with the second fluid pathway for a permeate flow, and a retentate outlet for a retentate flow;
- a second tangential flow filter having an intake and an outlet, the intake coupled to the retentate outlet of the first filter, and the outlet in fluid communication with the second fluid pathway of the catheter assembly;
- a pump configured to withdraw a volume of cerebrospinal fluid from the human or animal subject and transfer the volume of cerebrospinal fluid to the first tangential flow filter along the first fluid pathway;
- wherein the first and second tangential flow filters are is configured to filter the volume of cerebrospinal fluid into a permeate and a retentate;
- wherein the pump is configured to return at least a portion of the permeate to the human or animal subject along the second fluid pathway;
- and
- a processor configured for measuring a waste rate of the system, wherein the waste rate is the difference between the volume of fluid withdrawn from the subject and a volume of permeate returned to the subject over a period of time.
A system for filtering materials from cerebrospinal fluid (CSF) of a human or animal subject, the system comprising:
- a catheter assembly including a first fluid pathway and a second fluid pathway;
- a first tangential flow filter coupled to the catheter assembly, the first tangential flow filter having a fluid inlet in communication with the first fluid pathway, a permeate outlet in fluid communication with the second fluid pathway for a permeate flow, and a retentate outlet for a retentate flow;
- a second tangential flow filter having an intake and an outlet, the intake coupled to the retentate outlet of the first filter, and the outlet in fluid communication with the second fluid pathway of the catheter assembly;
- a pump configured to withdraw a volume of cerebrospinal fluid from the human or animal subject and transfer the volume of cerebrospinal fluid to the first tangential flow filter along the first fluid pathway;
- wherein the first and second tangential flow filters are configured to filter the volume of cerebrospinal fluid into a permeate and a retentate;
- wherein the pump is configured to return at least a portion of the permeate to the human or animal subject along the second fluid pathway;
- and
- one or more sensors for measuring a waste rate of the filtration system, wherein the waste rate is the difference between the volume of cerebrospinal fluid withdrawn from the subject through the first fluid pathway and a volume of permeate returned to the subject along the second fluid pathway.
A system for filtering materials from cerebrospinal fluid (CSF) of a human or animal subject, the system comprising:
- a catheter assembly including a first fluid pathway and a second fluid pathway;
- a first filter comprising a tangential flow filter configured to filter a volume of CSF into permeate and retentate, the first filter having a fluid inlet in communication with the first fluid pathway, a permeate outlet in fluid communication with the second fluid pathway for a permeate flow, and a retentate outlet for a retentate flow;
- a second filter having an intake and an outlet, the intake coupled to the retentate outlet of the first filter, and the outlet in fluid communication with the second fluid pathway of the catheter assembly;
- and
- a processing unit for calculating a waste rate of the system and modifying one or more parameters of the system that influence the waste rate to maintain the waste rate less than a preset threshold, wherein the waste rate is the difference between a volume of CSF removed from the subject through the first fluid pathway and a volume of CSF returned to the subject through the second fluid pathway.
Dependencies are inferred from the claim text.