Method and device for treating venous insufficiency and varicose veins

A method of treating a subject using a kit having a composition and a double tube injection and aspiration catheter, the method comprising:

• intravenously applying, at one or more sites of treatment, the composition by the double tube injection and aspiration catheter, the catheter having an outer tube and an inner tube, the outer tube having at least one side hole provided therein, the composition comprising:
• a) a pharmaceutically acceptable tissue glue that can polymerize on contact with H2O, blood or constituent parts of blood,
• b) a medical gas, for use in treating varicose veins, and
• c) a sclerosant drug;
• and
• performing the following steps at each of the one or more sites of treatment:
• aspirating blood of the subject through one or more holes of the at least one side hole provided in the outer tube to collapse a vein;
• administering the sclerosant drug as a first foam through one or more holes of the at least one side hole provided in the outer tube;
• aspirating the sclerosant drug through one or more holes of the at least one side hole provided in the outer tube;
• and
• applying the tissue glue and medical gas via the inner tube as a second foam or gel while maintaining negative pressure via the outer tube,
• wherein said medical gas is combined with said tissue glue to prepare the second foam or gel for injection within the vein,
• wherein said tissue glue and said medical gas are applied in a 1:1 to 1:4 ratio, and
• wherein said tissue glue is provided in an amount of 0.1 mL to 0.5 mL per injection.

A method of treating a subject using a kit having a composition and a double tube injection and aspiration catheter, the method comprising:

• intravenously applying, at one or more sites of treatment, the composition by the double tube injection and aspiration catheter, the catheter having an outer tube and an inner tube, the outer tube having at least one side hole provided therein, the composition comprising:
• a) a pharmaceutically acceptable tissue glue that can polymerize on contact with H2O, blood or constituent parts of blood,
• b) a medical gas, for use in treating varicose veins, and
• c) a sclerosant drug;
• and
• performing the following steps at each of the one or more sites of treatment:
• aspirating blood of the subject through one or more holes of the at least one side hole of the outer tube to collapse a vein;
• administering the sclerosant drug as a first foam through one or more holes of the at least one side hole of the outer tube;
• aspirating the sclerosant drug through one or more holes of the at least one side hole of the outer tube;
• and
• sequentially applying the medical gas and the tissue glue via the inner tube while maintaining negative pressure via the outer tube,
• wherein at least a first portion of the medical gas is applied in a first bolus and the tissue glue is subsequently applied in a second bolus, and
• wherein said tissue glue and said medical gas are applied in a 1:1 to 1:4 ratio, and
• wherein said tissue glue is provided in an amount of 0.1 mL to 0.5 mL per injection.