Methods and apparatus for kidney dialysis and extracorporeal detoxification
AssigneeHIBAR Microsciences LLC
InventorJames A. Tumlin
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Abstract
The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.
Claims8
A method of dialysis to remove a nonpolar, hydrophobic, and/or protein-bound uremic toxin from the blood or plasma of a subject, comprising subjecting the blood or plasma to an apparatus comprising a body having an inlet and an outlet and defining an interior, the interior including a membrane having a lipocalin family protein covalently bound thereon, the lipocalin family protein being one that binds to the uremic toxin, the apparatus being arranged so that the blood or plasma entering the apparatus contacts the lipocalin family protein in the interior of the apparatus.
Dependencies are inferred from the claim text.