Blood treatment systems and methods

A system for delivering an anticoagulant solution in a blood circuit of a hemodialysis apparatus comprising:

• a blood pump cassette comprising an anticoagulant metering pump, first and second diaphragm pumps, and a plurality of valves, the blood pump cassette configured for pumping blood from a cassette inlet connected to an arterial line to a cassette outlet connected to a venous line;
• a controller configured to control the metering pump, the first diaphragm pump and the plurality of valves to pump a bolus of the anticoagulant solution from a container connected to the blood pump cassette to a pumping chamber of the first diaphragm pump;
• the controller configured to control the first diaphragm pump to draw a first volume of dialysate solution into the pumping chamber before delivering the bolus of the anticoagulant solution and the first volume of dialysate solution to the blood pump cassette inlet or outlet;
• and
• the controller configured to control the first diaphragm pump to draw a second volume of dialysate solution into the pumping chamber after delivering the bolus of anticoagulant solution and the first volume of dialysate solution, and to deliver the second volume of dialysate solution to the blood pump cassette inlet or outlet.