Delivery of hydrophobic active agent particles
AssigneeSurModics, Inc.
InventorsJoram Slager, Toni M. Heyer, David E. Babcock
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Abstract
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
Claims13
A drug delivery coating comprising
- a base polymeric layer, the base polymeric layer comprising a hydrophilic surface and a photo-crosslinker comprising at least two aryl ketone functionalities;
- a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer comprising
- a particulate hydrophobic therapeutic agent;
- and
- a cationic agent, the cationic agent comprising polyethyleneimine (PEI);
- wherein a ratio (wt./wt.) of particulate hydrophobic therapeutic agent to the cationic agent is about 99.9/0.1 to 90/10.
Dependencies are inferred from the claim text.