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US 11,529,431 B2Granted
Methods for making ultrasound contrast agents
AssigneeLantheus Medical Imaging, Inc.
InventorsSimon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
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Abstract
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Claims28
A method of ultrasound contrast imaging a subject comprising
- (a) combining one or more phospholipids and a non-aqueous solvent, in a methanol and toluene free and methyl t-butyl ether free condition, to form a phospholipid solution having calcium and/or magnesium divalent metal cation present at a total divalent metal cation concentration of less than 0.7 ppm,
- (b) combining the phospholipid solution with an aqueous solution to form a phospholipid suspension,
- (c) activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres,
- (d) administering the lipid-encapsulated gas microspheres to a subject, and
- (e) obtaining an ultrasound image of the subject.
2 more elements
A method of ultrasound contrast imaging a subject comprising
- (a) selecting an MPEG5000-DPPE having calcium and/or magnesium divalent metal cation present at a total divalent metal cation concentration of less than 115 parts per million (ppm),
- (b) combining the MPEG-5000-DPPE with one or more phospholipids and a non-aqueous solvent, in a methanol and toluene free and methyl t-butyl ether free condition, to form a phospholipid solution having calcium and/or magnesium divalent metal cation present at a total divalent metal cation concentration of less than 0.7 ppm,
- (c) combining the phospholipid solution with an aqueous solution to form a phospholipid suspension,
- (d) activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres,
- (e) administering the lipid-encapsulated gas microspheres to a subject, and
- (f) obtaining an ultrasound image of the subject.
3 more elements
Dependencies are inferred from the claim text.