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US 11,529,430 B2Granted
Polydopamine decorated tobacco mosaic theranostic virus nanoparticles
AssigneeCase Western Reserve University
InventorNicole F. Steinmetz
Life of this patent
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Abstract
A nanoparticle for diagnostic, therapeutic, and/or theranostic applications includes a rod-shaped plant virus like particle (VLP), one or more gadolinium T1 contrast agents conjugated to an interior surface of the VLP, and a layer of polydopamine (PDA) coated over a portion of the exterior surface of the VLP.
Claims18
A nanoparticle comprising:
- a rod-shaped plant virus like particle (VLP), one or more gadolinium contrast agents conjugated to an interior surface of the VLP, and a layer of polydopamine (PDA) coated over a portion of the exterior surface of the VLP, wherein the nanoparticle PDA layer is prepared by in situ self-polymerization of dopamine.
A method of detecting and/or treating cancer in a subject in need thereof, comprising:
- administering to the subject a plurality of nanoparticles, the nanoparticles including rod-shaped plant virus like particles (VLPs), one or more gadolinium contrast agents conjugated to interior surfaces of the respective VLPs, and layers of polydopamine (PDA) coated over a portion of the exterior surfaces of the respective VLP, wherein the nanoparticle PDA layers are prepared by in situ self-polymerization of dopamine;
- detecting the nanoparticles in the subject using one or more imaging devices subsequent to administering the nanoparticles to determine the location and/or distribution of the cancer in the subject;
- and optionally
- delivering photothermal therapy (PTT) to the VLPs in the determined location of the cancer in the subject.
1 more element
Dependencies are inferred from the claim text.