Back to results
US 11,529,417 B2Granted
Wound healing through sirt1 overexpression
AssigneeNorthwestern University
InventorsGuillermo A. Ameer, Michele Jen, Jian Yang
Life of this patent
Estimating the term…
Abstract
Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients).
Claims4
A method of promoting wound healing in a mammalian subject comprising topically administering to the wound a composition comprising (a) an expression vector comprising a nucleic acid sequence with at least 70% sequence identity with SEQ ID NO:
- 1 and encoding a Sirt1 polypeptide that exhibits deacetylase activity and (b) a poly(polyethyleneglycol co-citric acid-co-N isopropylacrylamide) (PPCN) carrier material, under conditions that allow for overexpression of the Sirt1 polypeptide at the wound such that wound healing is promoted.
Dependencies are inferred from the claim text.