Viral vaccines for in vivo expression of a nucleic acid encoding an immunogenic peptide and methods of using the same
AssigneeOrbis Health Solutions LLC
InventorThomas E. Wagner
Life of this patent
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Abstract
The present disclosure provides particles for delivering a nucleic acid that encodes an immunogenic peptide in an antigen presenting cell. The disclosed particles can function as a vaccine and can be used to treat or prevent a viral or bacterial infection in a subject by expressing in vivo an immunogenic peptide, thereby stimulating the subject's immune system to attack the virus or bacteria that naturally express the immunogenic peptide.
Claims19
A SARS-CoV-2 vaccine comprising:
- (i) a yeast cell wall particle (YCWP) that is surface-modified with polyethyleneimine (PEI), (ii) a lysosome-evading component attached to the YCWP, and (iii) a deoxyribonucleic acid (DNA) sequence encoding a viral spike protein of SARS-CoV-2 or an immunogenic fragment thereof, wherein the nucleic acid is attached to the YCWP via a complex formed between the PEI and the nucleic acid, wherein intradermal administration of the SARS-CoV-2 vaccine to a human subject elicits an immunogenic response.
A vaccine comprising:
- (i) yeast cell wall particle (YCWP) that is surface modified with polyethyleneimine (PEI), (ii) an adenovirus attached to the YCWP, and (iii) a deoxyribonucleic acid (DNA) sequence encoding a SARS-CoV-2 viral spike protein or an immunogenic fragment thereof, wherein the adenovirus and the nucleic acid is attached to the YCWP by forming a complex with the PEI, wherein intradermal administration of the vaccine to a human subject elicits an immunogenic response.
A method of reducing a risk of infection from coronavirus disease 2019 (COVID-19) in a human subject comprising, administering to the human subject a vaccine comprising:
- (i) yeast cell wall particle (YCWP) that is surface modified with polyethyleneimine (PEI), (ii) a non-infectious and non-replicative adenovirus attached to the YCWP, and (iii) a deoxyribonucleic acid (DNA) sequence encoding a viral spike protein from SARS-CoV-2 or an immunogenic fragment thereof.
Dependencies are inferred from the claim text.