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US 11,529,410 B2Granted
Universal virus-like particle (VLP) influenza vaccines
AssigneeTechnoVax, Inc.
InventorsJose M. Galarza, George R. Martin
Life of this patent
Estimating the term…
Abstract
Described herein are influenza virus-like particles (VLPs) that display on truncated, re-engineered or remodeled HA molecules on their surface. Also described are methods of making and using these VLPs.
Claims21
A virus-like particle (VLP) comprising:
- at least one influenza matrix protein;
- and
- an antigenic influenza HA polypeptide displayed on the surface of the VLP, the HA polypeptide comprising an HA1 polypeptide and an HA2 polypeptide, the HA2 polypeptide having an extracellular domain, a transmembrane domain and a cytoplasmic domain, the extracellular domain of the HA2 polypeptide comprising at least 173 amino acid residues, and wherein the HA1 polypeptide consists of residues 17-65 and 241 to 346 of the HA1 polypeptide, as numbered relative to wild-type HA1 as set forth by SEQ ID NO:13.
Dependencies are inferred from the claim text.