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US 11,529,409 B2Granted
Influenza B virus mutants and uses therefor
AssigneeFluGen, Inc.
InventorsMichael J. Moser, Yasuko Hatta, Pamuk Bilsel
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Abstract
Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant BM2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
Claims19
A recombinant influenza B virus having a mutant BM2 gene comprising SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or SEQ ID NO:
- 5.
2 more elements
A composition comprising:
- a recombinant influenza B virus having a mutant BM2 gene comprising SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or SEQ ID NO:
- 5.
3 more elements
A method for propagating a recombinant influenza B virus, comprising:
- contacting a host cell with a recombinant influenza virus comprising SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or SEQ ID NO:
- 5;
- and incubating the host cell for a sufficient time and under conditions suitable for viral replication, wherein the host cell is modified to produce a functional version of the influenza BM2 gene, thereby providing the gene product to the virus in trans.
4 more elements
Dependencies are inferred from the claim text.