Isolation of a novel pestivirus causing congenital tremor A
AssigneeVeterinarmedizinische Universitat Wien
InventorsHans Tillmann Rümenapf, Benjamin Lamp, Lukas Schwarz
Life of this patent
Estimating the term…
Abstract
The present invention relates to a new pestivirus useful in the fields of veterinary virology and vaccines. Specifically, it relates to an isolated polynucleotide originating from pestivirus and a pestivirus, to vaccines and medical uses thereof, to chimeric virus comprising the polynucleotide and to expression vectors for heterologous expression of polypeptides.
Claims18
An isolated polynucleotide comprising a nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 or a sequence with at least 80% identity thereto, wherein the polynucleotide further comprises an exogenous polynucleotide.
An infectious polynucleotide comprising a sequence selected from the group consisting of SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, SEQ ID NO:
- 26, SEQ ID NO:
- 27, SEQ ID NO:
- 28, and SEQ ID NO:
- 29 or any combinations thereof or a sequence with at least 95% identity thereto, wherein the infectious polynucleotide further comprises an exogenous polynucleotide.
A composition comprising a porcine pestivirus having a nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 or a sequence with at least 80% identity thereto, wherein the composition further comprises an exogenous polynucleotide.
A composition comprising a porcine pestivirus comprising one or more amino acid sequences selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4 (Npro), SEQ ID NO:
- 5 (Core), SEQ ID NO:
- 6 (Erns), SEQ ID NO:
- 7 (E1), SEQ ID NO:
- 8 (E2), SEQ ID NO:
- 9 (P7), SEQ ID NO:
- 10 (NS2), SEQ ID NO:
- 11 (NS3), SEQ ID NO:
- 12 (NS4A), SEQ ID NO:
- 13 (NS4B), SEQ ID NO:
- 14 (NS5A) and SEQ ID NO:
- 15 (NS5B), wherein the composition further comprises a heterologous polypeptide.
A cell comprising a polynucleotide, wherein the polynucleotide comprises a nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 or a sequence with at least 80% identity thereto, the polynucleotide further comprising an exogenous polynucleotide.
A vector comprising a nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 or a sequence with at least 80% identity thereto, wherein the vector further comprises an exogenous polynucleotide.
Dependencies are inferred from the claim text.