MDR E. coli immunogen
AssigneeJanssen Pharmaceuticals, Inc.
InventorsEszter Nagy, Gäbor Nagy, Valéria Szijárto, Zóltan Magyarics, Irina Mirkina, Luis Gauchalla, Adriana Badarau, Gerhild Zauner, Jolanta Lukasiewicz
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Abstract
The subject relates to an isolated antibody that specifically binds to O25b antigen of multi drug resistant (MDR) E. coli strains, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated epitope recognized the specific antibody.
Claims27
An immunogen composition comprising:
- (a) an isolated O25b antigen having a repeating unit of the structure of:
- (b) an isolated second antigen not natively associated with the O25b antigen;
- and
- (c) a carrier.
An isolated O25b antigen having a repeating unit of the structure of:
- wherein the isolated O025b antigen is not covalently bound to a Lipid A.
An immunogen composition comprising:
- (a) an isolated O25b antigen having a repeating unit of the structure of:
- wherein the isolated O025b antigen is not covalently bound to a Lipid A, and
- (b) a carrier comprising an agent that when administered in conjunction with the O25b antigen augments and/or redirects the immune response to the O25b antigen, but when administered alone does not generate an immune response to the O025b antigen.
Dependencies are inferred from the claim text.