PCSK9 inhibitory polypolypeptides and methods of use
AssigneeInstitut de Cardiologie de Montreal
InventorsSteve Poirier, Gaetan Mayer
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Abstract
The present invention relates to PCSK9 inhibitors and methods of use thereof. Specifically, the invention relates to PCSK9 cell-based assay, PCSK9 inhibiting polypeptides and derivatives thereof. The invention includes pharmaceutical compositions comprising a PCSK9 inhibitor polypeptide together with a pharmaceutically acceptable carrier and method for treating cardiovascular disorders, hyperlipidemia, inflammatory diseases or inflammatory response to infection.
Claims13
A method of reducing circulating LDL-cholesterol levels in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a conjugated polypeptide comprising the amino acid sequence of SEQ. ID. NO. 4, wherein the conjugated polypeptide is conjugated to one or more polymer moieties, and wherein the conjugated polypeptide binds to PSCK9.
Dependencies are inferred from the claim text.