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US 11,529,371 B2Granted
Anti-CD33 antibody agents
AssigneeMemorial Sloan Kettering Cancer Center
InventorsSayed Shahabuddin Hoseini, Nai-Kong V. Cheung
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Abstract
Provided are anti-CD33 antibody agents, including anti-CD33 antibody agents in an IgG-scFv format. Various methods and reagents related thereto are also provided, including for example for the detection, prevention, and/or therapeutical treatment of CD33-related diseases, in particular, leukemias such as AML.
Claims19
A bispecific antibody agent comprising two identical immunoglobulin heavy chains and two identical fusion polypeptides, wherein each heavy chain comprises a heavy chain variable domain sequence that is SEQ ID NO:1 or 2, and wherein each fusion polypeptide comprises:
- (i) an immunoglobulin light chain comprising a light chain variable domain sequence that is SEQ ID NO:3 or 4, and
- (ii) a single chain variable fragment (scFv),
- wherein the heavy chain and the fusion polypeptide light chain bind to CD33, and wherein the fusion polypeptide scFv binds to CD3.
Dependencies are inferred from the claim text.