Halogenated salicylanilides for treating Clostridium infections
AssigneeUNION therapeutics A/S
InventorsMorten Otto Alexander Sommer, Rasmus Vendler Toft-Kehler, Daniel Jean Jacques Simon
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Abstract
The present invention relates to halogenated salicylanilides, or pharmaceutically acceptable salts or esters thereof, for use in the treatment of an infection in a subject caused by Clostridium bacteria, particularly a C. difficile infection. The halogenated salicylanilides are expected to be useful in the treatment of C. difficile associated diseases including C. difficile associated diarrhoea and C. difficile associated colitis.
Claims22
A method of treating an infection caused by Clostridium difficile bacteria in a subject, the method comprising administering to said subject an effective amount of a halogenated salicylanilide, or a pharmaceutically acceptable salt or ester thereof, wherein the halogenated salicylanilide is of the formula:
- wherein
- R1 and R2 are each independently halo;
- R5 is H or -L1-R7;
- L1 is selected from the group consisting of a bond and O;
- R7 is phenyl, unsubstituted or substituted with 1 or 2 groups each independently selected from the group consisting of halo and C1-4 alkyl;
- n is 1 or 2;
- p is 0 or 1.
Dependencies are inferred from the claim text.