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US 11,529,359 B2Granted
Use of GABAA receptor modulators for treatment of itch
AssigneeUniversitäT ZüRich
InventorsHanns Ulrich Zeilhofer, William Ralvenius
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Abstract
A compound for use in the treatment of itch is provided, wherein the compound comprises the general formula (1a), general formula (1b) or general formula (1c). The compounds of the invention are positive allosteric α2 and/or α3 GABAA receptor modulators.
Claims12
A method of treating a pruritic condition in a subject, comprising administering to the subject a compound that comprises the general formula (5a),
- wherein,
- R1 is an unsubstituted biphenyl or a substituted biphenyl comprising at least one —CN as a substituent;
- and
- R7 is an unsubstituted C1-C6 alcohol,
- wherein the compound is a positive, allosteric a2 or a3 GABAA receptor modulator.
2 more elements
Dependencies are inferred from the claim text.