SHP2 phosphatase inhibitors and methods of use thereof

A compound of formula (I), or a pharmaceutically acceptable salt thereof,

• wherein
• Rl is selected from the group consisting of
• each of R4 and R5 is, independently, H, OH, (C1-C6)alkyl, —O(C1-C6)alkyl, —(C1-C6)alkyl-O—R6, —C(O)NH2, —N(R6)2, halogen, —(C1-C6)alkyl-N(R6)2, or nitrile, wherein said —(C1-C6)alkyl, —O(C1-C6)alkyl, —(C1-C6)alkyl-O—R6, or —(C1-C6)alkyl-N(R6)2 is optionally substituted with one or more substituents selected from the group consisting of —OH, —N(R6)2, oxo, and halogen, wherein each R6 is independently H or —(C1-C6)alkyl;
• or R4 and R5, taken together with the atoms to which they are attached, form a 3-7 membered carbocyclic or heterocyclic ring, which ring is optionally substituted with —OH, —(C1-C6)alkyl, —O(C1-C6)alkyl, —N(R6)2, halogen, oxo, or nitrile;
• each of R11 and R12 is, independently, H, —OH, —(C1-C6)alkyl, —O(C1-C6)alkyl, —(C1-C6)alkyl-O—R6, —C(O)NH2, —N(R6)2, halogen, —(C1-C6)alkyl-N(R6)2, —CO2H, or nitrile, wherein said —(C1-C6)alkyl, —O(C1-C6)alkyl, —(C1-C6)alkyl-O—R6, or —(C1-C6)alkyl-N(R6)2 is optionally substituted with one or more substituents selected from the group consisting of —OH, —N(R6)2, and halogen;
• each of Rg and R9 is, independently, H, —(C1-C6)alkyl, —(C1-C6)alkyl-N(R6 —OR6, —(C1-C6)alkyl-O—R6, —C(O)NH2, —N(R6)2, halogen, or nitrile;
• and each of m and n is, independently, 0, 1, 2, or 3, with m+n being no more than 4.