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US 11,529,343 B2Granted
Compositions and methods for identifying and treating dystonia disorders
AssigneeDuke University
InventorsNicole Calakos, Zachary F. Caffall, Joseph Rittiner
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Abstract
The present disclosure provides methods and compositions for the treatment, identification, diagnosis, and prognosis of dystonia, or dystonia related disorders.
Claims15
A method of monitoring disease progression and tailoring treatment of dystonia in a subject in need thereof, the method comprising:
- (a) obtaining a first biological sample from a subject;
- (b) determining the expression level of activation transcription factor (ATF4) in the first biological sample;
- (c) administering an agent for the treatment of dystonia to the subject;
- (d) obtaining a second biological sample from the subject;
- (e) determining the expression level of ATF4 in the second biological sample;
- (f) comparing the expression levels of ATF4 in the first and second samples;
- (g) determining that the subject has improved dystonia if the level of ATF4 in the second sample is increased relative to the level of ATF4 in the first sample;
- and
- (h) continuing administration of the agent for the treatment of dystonia, thereby treating dystonia.
6 more elements
Dependencies are inferred from the claim text.