Materials and methods for improving lung function and for prevention and/or treatment of radiation-induced lung complications
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsSadasivan Vidyasagar, Paul Okunieff
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Abstract
The subject invention provides therapeutic compositions and uses thereof for improving pulmonary function. In one embodiment, the therapeutic composition comprises one or more free amino acids selected from lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, tryptophan, asparagine, and serine; and electrolytes. In one embodiment, the subject invention can be used to prevent or treat long-term lung complications induced by radiation.
Claims15
A method for treating at least one lung complication induced by radiation in a human subject in need thereof, wherein the method comprises:
- administering, to the human subject in need thereof, an effective amount of a therapeutic formulation comprising free amino acids, the free amino acids consisting essentially of free amino acids of lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, and serine;
- and
- optionally, tryptophan;
- wherein the human subject in need thereof receives radiation at a dose capable of causing lung injury,
- wherein the therapeutic formulation is administered via inhalation, and
- wherein the effective amount is sufficient to improve pulmonary function impaired by the at least one lung complication induced by radiation in the human subject in need thereof.
Dependencies are inferred from the claim text.