Methods and compositions for the treatment of cancer cachexia
AssigneeOhio State Innovation Foundation
InventorsChing-Shih Chen, Christopher C. Coss, Samuel Kulp, Yu-Chou Tseng, Tanios Bekaii-Saab
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Abstract
In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.
Claims2
A method for treating cancer cachexia in a subject, comprising administering to the subject a therapeutically effective amount of
- AR-42, having the following chemical structure:
- and
- GTx-024, having the following chemical structure:
Dependencies are inferred from the claim text.