Devices and methods for local delivery of tacrolimus
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Department of Veterans Affairs
InventorsKia M. Washington, William R. Wagner, Michael Brandt Steketee, Yolandi Van der Merwe, Xinzhu Gu
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Abstract
Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.
Claims30
A device for local delivery of tacrolimus, comprising a polymeric matrix, wherein the polymeric matrix comprises an effective amount of a biodegradable polymer and tacrolimus,
- wherein the polymeric matrix is in a form of an electrospun nerve wrap having a Young's modulus between from about 5 MPa to about 50 MPa, suture retention strength of at least 100 gram-force, an ultimate stress of from about 3 MPa to about 9 MPa, and a strain at break between from about 50% to about 300%;
- wherein the electrospun nerve wrap is impregnated with the tacrolimus in an amount of from about 1 mg to about 100 mg, wherein the tacrolimus and biodegradable polymer are impregnated in a weight ratio of from about 1:20 to about 1:50 in the electrospun nerve wrap.
Dependencies are inferred from the claim text.