Modified guanidine-containing polymers for biologic delivery
AssigneeThe Florida International University Board of Trustees
InventorsJoong Ho Moon, Alfonso Barrios, Mario Milan Diaz
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Abstract
The subject invention provides materials and methods for intracellular deliver of molecules and/or therapeutic agents. The subject invention also provides methods for synthesizing polymeric systems and nanomaterials that enhance or assist the passage of molecules and/or therapeutic agents across biological membranes. The compound, polymer or nanoparticle of the subject invention comprises a modified guanidine moiety in a plurality of repeating units of a polymer or on the surface of a nanoparticle where the guanidine moiety comprises, for example, a carbamoyl or thiourea modification. The polymer or nanoparticle can be used in a cancer treatment formulation.
Claims20
A compound comprising a plurality of repeating units, each repeating unit comprising structures selected from:
- wherein n≥1;
- W is O, S or Se;
- and Y and Y′ are each independently selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, cycloalkenyl, and substituted cycloalkenyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, amino, hydroxyl, alkynyl, haloalkyl, acyl, alkylamino, arylamino and hydroxylalkyl.
Dependencies are inferred from the claim text.