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US 11,529,312 B2Granted
Francisella lipids as broad anti-inflammatory therapeutics and associated methods of use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsCatharine Mans Bosio, Robin M. Ireland, Glenn A. Nardone
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Abstract
Embodiments of the present disclosure include anti-inflammatory compositions and methods of use thereof. The compositions include purified lipids from Francisella, for example, virulent strains of Francisella. Other features and advantages of the invention will be apparent from the detailed description, and from the claims.
Claims15
A liposome comprising:
- a synthetic phosphatidylethanolamine (PE) comprising two acyl chains, wherein one acyl chain has a length of 10 carbons and one acyl chain has a length of 24 carbons;
- and
- a synthetic phosphatidylcholine (PC) comprising two acyl chains, wherein both acyl chains have a length of 24 carbons
- wherein the ratio of PE:PC in the liposome is in a range from about 50:50 to about 95:5, and wherein the liposome comprises anti-inflammatory properties that inhibit inflammation resulting from a microbial infection.
1 more element
A liposome consisting essentially of:
- a synthetic PE comprising two acyl chains, wherein one acyl chain has a length of 10 carbons and one acyl chain has a length of 24 carbons, and a synthetic phosphatidylcholine (PC) comprising two acyl chains, wherein both acyl chains have a length of 24 carbons,
- wherein the ratio of PE:PC in the liposome is in a range from about 50:50 to about 95:5, and wherein the liposome comprises anti-inflammatory properties that inhibit inflammation resulting from a microbial infection.
A liposome consisting of:
- a synthetic PE comprising two acyl chains, wherein one acyl chain has a length of 10 carbons and one acyl chain has a length of 24 carbons, and a synthetic phosphatidylcholine (PC) comprising two acyl chains, wherein both acyl chains have a length of 24 carbons,
- wherein the ratio of PE:PC in the liposome is in a range from about 50:50 to about 95:5, and wherein the liposome comprises anti-inflammatory properties that inhibit inflammation resulting from a microbial infection.
Dependencies are inferred from the claim text.