US 11,529,306 B2 · Lyophilized formulation of stem cell-derived exosomes and anti-inflammatory composition including the same as active ingredient

Abstract

The lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to stabilize stem cell-derived exosomes and exhibit excellent anti-inflammatory effects, and particularly, exhibit remarkable anti-inflammatory effects as compared with not-lyophilized stem cell-derived exosomes isolated and purified from conditioned media of stem cells. Therefore, the lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to effectively prevent, suppress, alleviate, ameliorate or treat inflammatory response or inflammatory diseases.

Claims28

Dependent claims

An anti-inflammatory composition comprising:

a lyophilized formulation of stem cell-derived exosomes comprising stem cell-derived exosomes, and a combination of methionine, mannitol and trehalose as a cryoprotectant;
and
a diluent;
wherein the diluent comprises water for injection, physiological saline, phosphate buffered saline, purified water, or deionized water;
and
wherein the diluent further comprises hyaluronic acid or hyaluronate.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/913,624Filed 26 Jun 2020 · continuation

Priority

KR 10-2018-008835430 Jul 2018

Published

US 2020/0323768 A115 Oct 2020

Granted

20 Dec 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification22 codes

A61K 8/981
Of animal origin: of mammals or bird
A61K 8/044
Dispersions; Emulsions: suspensions
A61K 8/735
Polysaccharides: mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
A61K 8/925
Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof: of animal origin

Lyophilized formulation of stem cell-derived exosomes and anti-inflammatory composition including the same as active ingredient

Life of this patent

Lyophilized formulation of stem cell-derived exosomes and anti-inflammatory composition including the same as active ingredient

Life of this patent

Abstract

Claims28