System and method for disease risk assessment and treatment

A biosensor assembly measuring multiple parameters, comprising:

• a skin contacting surface that includes a first skin contacting electrode being located on a bottom of the biosensor assembly;
• and
• a first implantable probe extending away from the skin contacting surface, the first implantable probe being inserted through skin of a subject, the first implantable probe enabling signaling within subcutaneous tissue with a first working electrode and a second working electrode;
• wherein the biosensor assembly is configured to measure a first physiological parameter between the first implantable probe and the first skin contactable electrode, the first physiological parameter being tissue impedance measured between the skin contacting electrode and either the first or second working electrode of the first implantable probe within subcutaneous tissue.