Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea

A measurement system for a cornea, comprising:

• a light source configured to emit light;
• at least one optical element positioned to receive the light from the light source and configured to focus the light to an area of corneal tissue at a selected depth of the cornea, a light signal being generated at the area of corneal tissue in response to the light from the light source;
• a pinhole structure including an aperture, the pinhole structure positioned to receive the light signal generated at the area of corneal tissue, the aperture being configured to selectively transmit the light signal from the area of corneal tissue at the selected depth;
• a detector positioned to capture the light signal transmitted by the aperture and configured to communicate information relating to a measurement of the light signal captured by the detector, wherein the pinhole structure prevents light above or below the selected depth from reaching the detector;
• and
• a controller communicatively coupled to the detector and configured to receive the information from the detector and to determine, based on the information, a measurement of the light signal generated at the area of corneal tissue at the selected depth.