Composition comprising Siallylactose for use in enhancing learning skills and memory function
AssigneeSociete des Produits Nestle S.A.
InventorsZhizhong Dong, Yujie Shi, Bing Wang
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Abstract
This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3′-Siallylactose (3′-SL) and 6′-Siallylactose (6′-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.
Claims16
A method for enhancing learning skills and/or enhancing memory function in an individual in need thereof by increasing the sialic acid concentration in the brain of the individual, the method comprising administering a nutritional composition comprising 3′-Sialyllactose (3′-SL) and 6′-Sialyllactose (6′-SL) in a weight ratio between 10:1 and 1:10 to the individual,
- wherein the individual has at least one characteristic selected from the group consisting of preterm, small for gestational age (SGA), and low birth weight (LBW),
- the nutritional composition does not contain N-acetylated oligosaccharide,
- the 3′-Sialyllactose (3′-SL) and the 6′-Sialyllactose (6′-SL) are administered to the individual during the first two weeks after birth in an amount comprising from 150 mg to 170 mg of total sialyllactose per kg body weight per day and/or from 450 mg to 530 mg of N-Acetyl-neuraminic acid (Neu5Ac) per kg body weight per day;
- and
- the 3′-Sialyllactose (3′-SL) and the 6′-Sialyllactose (6′-SL) are administered to the individual from the first two weeks after birth up to 2 months after birth in an amount comprising from 120 mg to 140 mg of total sialyllactose per kg body weight per day and/or from 350 mg to 430 mg of Neu5Ac per kg body weight per day.
Dependencies are inferred from the claim text.