US 11,524,066 B2 · Henipavirus vaccine

Abstract

The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Henipavirus, particularly Hendra virus and/or Nipah virus or a disorder related to such an infection. In particular, the present invention concerns a Hendra virus and/or Nipah virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.

Claims19

Dependent claims

A method of treating or preventing a disorder, wherein the method comprises applying or administering to a subject in need thereof an effective amount of a composition comprising a RNA comprising at least one coding sequence encoding a Nipah virus fusion protein F:

(a) at least about 95% identical to the sequence of SEQ ID NO:
1 and wherein the Nipah virus fusion protein F is encoded by a RNA coding sequence at least about 95% identical to SEQ ID NO:
53;
or
(b) at least about 95% identical to the sequence of SEQ ID NO:
573 and wherein the Nipah virus fusion protein F is encoded by a RNA coding sequence at least about 95% identical to SEQ ID NO:
625.

4 more elements

Dependencies are inferred from the claim text.

Henipavirus vaccine

Life of this patent

Henipavirus vaccine

Life of this patent

Abstract

Claims19