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US 11,512,347 B2Granted
Flexible substrates for nucleic acid synthesis
AssigneeTwist Bioscience Corporation
InventorBill James Peck
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Abstract
Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Additionally, devices described herein for de novo synthesis of oligonucleic acids encoding information related to the original source information may have a flexible material for oligonucleic acids extension.
Claims23
A device for information storage, the device comprising:
- a) a flexible structure in the form of a continuous tape having a surface, wherein the structure comprises a fiducial marking for aligning the structure;
- and
- b) a plurality of features on the surface, wherein each feature has a width of from about 1 to about 500 um, and wherein each feature of the plurality of features is coated with a moiety that binds to the surface and comprises a reactive group available for nucleoside coupling;
- and
- c) a plurality of oligonucleotides, wherein each of the oligonucleotides is bound to each of the plurality of features, wherein the plurality of oligonucleotides comprise predetermined sequences that collectively encode for an item of information comprising digital sequences encrypted as nucleic acid sequences and wherein each of the oligonucleotides comprises an index which provides instructions for assembling digital sequences;
- wherein when the plurality of oligonucleotides are released from the surface of the flexible structure, sequenced, decrypted, and assembled to form the digital sequences, the digital sequences are recovered with greater than 90% accuracy.
3 more elements
Dependencies are inferred from the claim text.