Enhanced organogenesis through manipulation of LIN28/LET-7/DIS3L2
AssigneeChildren's Medical Center Corporation
InventorsGeorge Q. Daley, Alena V. Yermalovich, Jihan K. Osborne
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Abstract
Described herein are methods of prolonging or reactivating organogenesis in a subject in need thereof (e.g., a subject that has impaired organ function such as a prematurely born infant). The methods comprise increasing the expression or activity of Lin28A or Lin28B proteins, inhibiting the expression or activity of let-7 family microRNAs, and/or inhibiting the expression or activity of Dis3L2 exonuclease.
Claims10
A method of prolonging or reactivating kidney organogenesis, the method comprising administering to a subject in need thereof an effective amount of an agent that inhibits the expression or activity of let-7a, let-7d, and let-7f microRNAs.
A method of prolonging organogenesis in an embryonic kidney, the method comprising inhibiting the expression or activity of let-7a, let-7d, and let-7f microRNAs in the embryonic kidney.
Dependencies are inferred from the claim text.