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US 11,512,294 B2Granted
Cyclic GMP-chelating peptides for subcellular targeting
AssigneesSorbaoone Universite, Centre National De La Recharche Scientifique, Institut National De La Sante Et La Recherche Medicale (INSERM)
InventorsXavier Nicol, Oriol Ros Torres
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Abstract
The disclosure pertains to the field of molecular means capable of binding to, and preferably of chelating, cGMP, appropriate for use in vitro or in vivo and preferably capable of targeting specific cellular compartments. The polypeptides of the disclosure comprise a chimeric construction derived from the N terminus part of PKG-Iα and PKG-Iβ, and the two cGMP binding sites of the wild type PKG.
Claims11
A polypeptide comprising:
- a chimeric peptide comprising at least a sequence corresponding to SEQ ID NO:
- 1 or a fragment thereof, and at least a sequence corresponding to SEQ ID NO:
- 2 or a fragment thereof;
- a cGMP binding domain comprising the sequence as set forth in SEQ ID NO:
- 6;
- and,
- wherein said polypeptide is devoid of any catalytic domain,
- and its functional variants that bind cGMP and have a sequence with at least 80% identity with the sequence of said polypeptide and which derives from the sequence of said polypeptide by conservative substitutions.
5 more elements
Dependencies are inferred from the claim text.