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US 11,512,034 B2Granted
Processes for the preparation of ortho-allylated hydroxy aryl compounds
AssigneeMcMaster University
InventorsJakob Magolan, Nicholas Jentsch, Xiong Zhang, Mathew Piotrowski
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Abstract
The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
Claims21
A process for preparing a compound of Formula (I-A)
- comprising:
- reacting a compound of Formula (II)
- with a compound of Formula (III)
- in the presence of acidic alumina and in a non-protic solvent to form the compound of Formula (I-A),
- wherein
- R1 is C1-12alkyl;
- R2 is H;
- R3 is selected from H and CH3;
- R4 is selected from H and CH3;
- and
- R5 is selected from
- wherein
- represents a point of covalent attachment.
10 more elements
Dependencies are inferred from the claim text.