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US 11,510,967 B2Granted
Pharmaceutical combinations comprising insulin and at least an agent selected from meloxicam, bromfenac sodium, acetylsalicylic acid, salicyclic acid and paracetamol
AssigneeEli Lilly and Company
InventorsJohn Michael Beals, Eric Dwayne Hawkins, Anthony Shane Ransdell, Shantanu Virendra Sule, Monica Rixman Swinney
Life of this patent
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Abstract
The present invention relates to pharmaceutical insulin compositions comprising insulin, a preservative, and at least one selected from the group consisting of aspirin, acetaminophen, dexamethasone, heparin, meloxicam, bromfenac sodium, salicylic acid; and the use of the compositions to treat diabetes.
Claims11
A pharmaceutical composition comprising an insulin selected from rapid acting insulin or ultra-rapid acting insulin, wherein the insulin concentration is from about 100 U/mL to about 500 U/mL;
- about 2.5 mg/mL to about 3.8 mg/mL of m-cresol;
- and about 0.025 mg/mL to about 3.0 mg/mL of meloxicam, wherein the composition has a pH between about pH 7 to about pH 7.8 at room temperature.
Dependencies are inferred from the claim text.