Pharmaceutical salts/co-crystals of pentoxifylline, clonidine and linsidomine with caffeic, protocatechuic or alpha-lipoic acid an use thereof for treatment of pain
AssigneeThe Royal Institution for the Advancement of Learning/Mcgill University
InventorsTerence J. Coderre, Oli Abate Fulas, André Laferrière, Ghada Ayoub, Tomislav Fri{hacek over (s)}{hacek over (c)}ić, Dayaker Gandrath, Cristina Mottillo
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Abstract
Disclosed are pharmaceutical salts and co-crystals of pentoxifylline, clonidine and linsidomine with caffeic acid, protocatechuic acid or α-lipoic acid, and method for preparing thereof. Also disclosed are topical compositions comprising said salts or co-crystals and use thereof for treating pain.
Claims17
A compound salt/co-crystal selected from pentoxifylline caffeate, pentoxifylline protocatechuate, clonidine α-lipoate and linsidomine caffeate or a solvate thereof.
A method for preventing or treating pain comprising topically administering an effective amount of a salt/co-crystal selected from pentoxifylline caffeate, pentoxifylline protocatechuate, clonidine α-lipoate and linsidomine caffeate or a solvate thereof to a subject in need thereof.
A method for preparing pentoxifylline caffeate, pentoxifylline protocatechuate, clonidine α-lipoate or linsidomine caffeate salt/co-crystal or a solvate thereof, comprising liquid-assisted grinding of an equimolar quantities of pentoxifylline with caffeic acid, pentoxifylline with protocatechuic acid, clonidine with α-lipoic acid or a caffeate salt with a linsidomine salt.
Dependencies are inferred from the claim text.