Use of anthranilic acid derivative as matrix for MALDI mass spectrometry
AssigneeNational Taiwan University
InventorsCheng-Chih Hsu, Pi-Tai Chou, Chuping Lee, Peng-Hsuan Huang, Li-En Lin, Chun-Ying Huang, Ta-Chun Lin
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Abstract
A use of an anthranilic acid derivative as a matrix for a MALDI Mass spectrometry, comprising: preparing a matrix compound represented by the following formula: wherein X is selected from hydrogen and a hydroxyl group, and Y is selected from hydrogen, a methyl group or an acetyl group, provided that when X is hydrogen, Y is hydrogen or an acetyl group, and when X is a hydroxyl group, Y is a methyl group; applying the matrix compound and an analyte onto a sample holder; and analyzing the analyte by the MALDI mass spectrometer.
Claims15
A method for providing a dual polarity sample for detecting biomolecules, said sample comprising a matrix compound and an analyte for processing by a MALDI Mass spectrometer, comprising:
- preparing the matrix compound comprising an anthranilic acid derivative represented by the following formula:
- wherein X is selected from hydrogen and a hydroxyl group, and Y is selected from hydrogen, a methyl group or an acetyl group, provided that when X is hydrogen, Y is hydrogen or an acetyl group, and when X is a hydroxyl group, Y is a methyl group;
- applying the matrix compound and the analyte onto a sample holder to form the sample comprising the matrix compound and the analyte;
- and
- administering the sample holder with the sample comprising the matrix compound and the analyte to the MALDI mass spectrometer.
Dependencies are inferred from the claim text.