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US 11,505,788 B2Granted
Fusion proteins and methods thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAntonio Iavarone, Anna Lasorella, Raul Rabadan
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Abstract
The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
Claims9
A purified EGFR-Septin-14 (EGFR-SEPT14) fusion protein comprising an EGFR portion fused to a Septin-14 portion, wherein the EGFR portion comprises the tyrosine kinase domain of EGFR
- and wherein the Septin-14 portion comprises a coiled-coil domain of a Septin-14 protein, wherein the EGFR-SEPT14 fusion protein comprises SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.