Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof
AssigneeDana-Farber Cancer Institute, Inc.
InventorsWayne A. Marasco, Xianchun Tang
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Abstract
The present invention provides antibodies that neutralize MERS-CoV and methods of use thereof. The invented antibody is used to treat MERS-CoV infections and symptoms thereof.
Claims33
An isolated monoclonal antibody, wherein said monoclonal antibody comprises a VH amino acid sequence having SEQ ID NO:
- 10, and a VL amino acid sequence having SEQ ID NO:
- 12.
An isolated scFv antibody, wherein said antibody comprises a VH amino acid sequence having SEQ ID NO:
- 10, and a VL amino acid sequence having SEQ ID NO:
- 12.
An isolated monoclonal antibody, wherein said monoclonal antibody comprises a heavy chain with three CDRs comprising the amino acid sequences GGTFSSYA (SEQ ID NO:35), IIPIFGKA (SEQ ID NO:36), and ARDQGISANFKDAFDI (SEQ ID NO:37]) respectively and a light chain with three CDRs comprising the amino acid sequences ESVGSN (SEQ ID NO:52]), GAS (SEQ ID NO:53]), and QQYNNWPLT (SEQ ID NO:54) respectively.
Dependencies are inferred from the claim text.