Therapeutics for the treatment of glaucoma
AssigneesMayo Foundation for Medical Education and Research, Regents of the University of Minnesota
InventorsMichael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
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Abstract
The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
Claims37
A method to treat increased intraocular pressure, glaucoma, ocular hypertension, retinopathy, or age-related macular degeneration to a host in need thereof comprising administering an effective amount of a compound of the formula:
- optionally in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.